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Invitrogen
DERL2 Polyclonal Antibody
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FIGURE: 1 / 6
DERL2 Antibody (PA5-115111) in ICC/IF
Immunocytochemistry analysis of DERL2 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115111) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-115111
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DERL2(Accession Q9GZP9), corresponding to amino acid residues P193-G239.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2899747
Product Specific Information
Antibody detects endogenous levels of total DERL2.
Target Information
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: carcinoma related; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; derlin 2; Derlin-2; derlin-2-like; DERtrin-2; F-LAN-1; F-LANa
Gene Aliases: CGI-101; DER2; DERL2; Derlin-2; DERtrin-2; F-LAN-1; F-LANa; FLANA; SBBI53
UniProt ID: (Human) Q9GZP9, (Mouse) Q8BNI4
Entrez Gene ID: (Human) 51009, (Mouse) 116891, (Rat) 100910823
suckling behavior
positive regulation of cell proliferation
positive regulation of cell growth
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
retrograde protein transport, ER to cytosol
response to unfolded protein
negative regulation of retrograde protein transport, ER to cytosol
endoplasmic reticulum mannose trimming
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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