Invitrogen

Caspase 10 Polyclonal Antibody

Product Details

PA1-4300

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide to the N terminus: M(1) K S Q G Q H W Y S S S D K N(15)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Wet ice

AB_557939

Product Specific Information

PA1-4300 detects the Caspase 10 protein in human, mouse, rat, and chicken samples.

PA1-4300 has been successfully used in Western blot procedures.

PA1-4300 immunizing peptide is the N terminal sequence of all isoforms of human Caspase-10.

Target Information

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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