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Invitrogen
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Immunogen sequence: KEKALVEVAA SSGPPTLTSL NIPPGPYSSM HKLLETQSTG ACQSSCKISS PCLKADSGAC GPDSCPYCAR AGAGEVELAD REMPDSDSEA VYEFTQDAQH SDLRDPHSRR QRSLGPDAEP S
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an alpha-1 subunit, an intracellular beta subunit, a disulfide linked alpha-2/delta subunit and a transmembrane gamma subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. T-type Ca2+ currents are activated and inactivated more rapidly and at more negative membrane potentials than other Ca2+ current types. T-type Ca2+ channels enhance odor sensitivity by lowering the threshold of spike generation in olfactory receptor cells (ORCs).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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