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Invitrogen
CaV2.1 Polyclonal Antibody
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CaV2.1 Antibody (PA5-64165)
Relative expression in different tissues in IHC: Detection of differential expression levels of CaV2.1 demonstrates antibody specificity. Immunohistochemical analysis of CaV2.1 using anti-CaV2.1 Polyclonal Antibody (Product # PA5-64165), shows significant staining of CaV2.1 in human cerebral cortex and shows minimal or weak staining in human pancreas tissues. The relative expression levels of CaV2.1 within... View More
Product Details
PA5-64165
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Calcium Channel 1A
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2639223
Product Specific Information
Immunogen sequence: KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGI
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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