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Invitrogen
CSN2 Polyclonal Antibody
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FIGURE: 1 / 2
CSN2 Antibody (PA1-24686) in IHC (P)
Immunohistochemical analysis of CSN2 in formalin-fixed, paraffin-embedded human prostate carcinoma (left) and mouse squamous cell carcinoma (right) using a CSN2 polyclonal antibody (Product # PA1-24686) at a dilution of 1:5000 (0.2µg/ml) and 1:1,000 (1µg/ml) and detected using DAB.
Product Details
PA1-24686
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a portion of human COP9 signalosome complex subunit 2 encoded within exons 1 and 2 (LocusLink ID 9318).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PA1-24686 detects CSN2 from human samples. PA1-24686 is expected to cross react with mouse due to sequence homology.
PA1-24686 has been successfully used in Western blot procedures.
The PA1-24686 immunogen is a synthetic peptide corresponding to a portion of human COP9 signalosome complex subunit 2 encoded within exons 1 and 2 (LocusLink ID 9318).
Target Information
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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