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Proteintech
CREBL2 Polyclonal Antibody
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Product Details
18007-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CREBL2 Fusion Protein Ag12504 (1-120 aa encoded by BC106052)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDDSKVVGG KVKKPGKRGR KPAKIDLKAK LERSRQSARE CRARKKLRYQ YLEELVSSRE RAICALREEL EMYKQWCMAM DQGKIPSEIK ALLTGEEQNK SQQNSSRHTK AGKTDANSNS W (1-120 aa encoded by BC106052)
Target Information
cAMP response element-binding protein-like-2 was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cAMP responsive element binding protein-like 2; cAMP-responsive element-binding protein-like 2; MHBs-binding protein 1
Gene Aliases: AI046348; B230205M03; CREBL2
UniProt ID: (Human) O60519, (Mouse) Q32M00, (Rat) Q5BJU6
Entrez Gene ID: (Human) 1389, (Mouse) 232430, (Rat) 362453
transcription, DNA-templated
regulation of transcription, DNA-templated
cell differentiation
positive regulation of peptidyl-serine phosphorylation
positive regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
positive regulation of glucose import
positive regulation of lipid biosynthetic process
protein stabilization
cell cycle
signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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