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Invitrogen
COPS7A Polyclonal Antibody
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FIGURE: 1 / 2
COPS7A Antibody (PA5-48458) in IHC (P)
Immunohistochemical analysis of COPS7A in formalin fixed and paraffin embedded human pancreas tissue. Samples were probed with a COPS7A Antibody (C-term) (Product # PA5-48458) followed by peroxidase conjugation of the secondary antibody and DAB staining.
Product Details
PA5-48458
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Conjugate
Form
Liquid
Concentration
Lot-Specific
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2633915
Product Specific Information
Predicted to react with mouse based on sequence homology.
Target Information
The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I B-alpha and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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