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Abnova
CNNM3 Polyclonal Antibody, MaxPab™
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Product Details
H00026505-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CNNM3 (AAH07199, 1 a.a. approximately 355 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLDASTVLDF GVLASIMQSG HTRIPVYEEE RSNIVDMLYL KDLAFVDPED CTPLSTITRF YNHPLHFVFN DTKLDAVLEE FKRGDTVVKR KPASLMAPLK RKEEFSLFKV SDDEYKVTIS PQLLLATQRF LSREVDVFSP LRISEKVLLH LLKHPSVNQE VRFDESNRLA THHYLYQRSQ PVDYFILILQ GRVEVEIGKE GLKFENGAFT YYGVSALTVP SSVHQSPVSS LQPIRHDLQP DPGDGTHSSA YCPDYTVRAL SDLQLIKVTR LQYLNALLAT RAQNLPQSPE NTDLQVIPGS QTRLLGEKTT TAAGSSHSRP SLPLLPRGRD SAAYSDSDLF GLSHLVSAVT AFVWP
Target Information
CNNM3, also known as cyclin M3, is part of the CNNM family of proteins that play a critical role in magnesium ion transport across cellular membranes. This gene is notably expressed in the proximal tubule of the kidney, and its protein product localizes to the lateral membrane, suggesting its involvement in magnesium homeostasis. The structural analysis of the CNNM3 protein reveals it contains a cyclic nucleotide-binding homology domain with a characteristic beta-roll structure capped by an α-helical bundle, which is typical of cyclic nucleotide-binding domains. CNNM proteins were originally discovered in bacteria and are conserved across various organisms, indicating their fundamental biological importance. CNNM3 has been studied for its ability to decrease whole cellular magnesium content and free intracellular magnesium activity when expressed in model systems such as Xenopus laevis oocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ancient conserved domain protein 3; Ancient conserved domain-containing protein 3; cyclin M3; Cyclin-M3; Metal transporter CNNM3
Gene Aliases: ACDP3; CNNM3
UniProt ID: (Human) Q8NE01
Entrez Gene ID: (Human) 26505
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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