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Proteintech
CNNM3 Polyclonal Antibody
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Product Details
13976-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CNNM3 Fusion Protein Ag5012 (358-707 aa encoded by BC037272)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NIVDMLYLK DLAFVDPEDC TPLSTITRFY NHPLHFVFND TKLDAVLEEF KRGKSHLAIV QKVNNEGEGD PFYEVLGLVT LEDVIEEIIR SEILDESEDY RDTVVKRKPA SLMAPLKRKE EFSLFKVSDD EYKVTISPQL LLATQRFLSR EVDVFSPLRI SEKVLLHLLK HPSVNQEVRF DESNRLATHH YLYQRSQPVD YFILILQGRV EVEIGKEGLK FENGAFTYYG VSALTVPSSV HQSPVSSLQP IRHDLQPDPG DGTHSSAYCP DYTVRALSDL QLIKVTRLQY LNALLATRAQ NLPQSPENTD LQVIPGSQTR LLGEKTTTAA GSSHSRPGVP VEGSPGRNPG V (358-707 aa encoded by BC037272)
Target Information
CNNM3, also known as cyclin M3, is part of the CNNM family of proteins that play a critical role in magnesium ion transport across cellular membranes. This gene is notably expressed in the proximal tubule of the kidney, and its protein product localizes to the lateral membrane, suggesting its involvement in magnesium homeostasis. The structural analysis of the CNNM3 protein reveals it contains a cyclic nucleotide-binding homology domain with a characteristic beta-roll structure capped by an α-helical bundle, which is typical of cyclic nucleotide-binding domains. CNNM proteins were originally discovered in bacteria and are conserved across various organisms, indicating their fundamental biological importance. CNNM3 has been studied for its ability to decrease whole cellular magnesium content and free intracellular magnesium activity when expressed in model systems such as Xenopus laevis oocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ancient conserved domain protein 3; Ancient conserved domain-containing protein 3; cyclin M3; Cyclin-M3; mACDP3; Metal transporter CNNM3
Gene Aliases: ACDP3; Clp3; CNNM3; mACDP3
UniProt ID: (Human) Q8NE01, (Mouse) Q32NY4
Entrez Gene ID: (Human) 26505, (Mouse) 94218, (Rat) 301345
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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