Invitrogen

CHMP4A Polyclonal Antibody

CHMP4A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CHMP4A Antibody (PA5-117867) in IHC (P)

Immunohistochemical staining of human CHMP4A in human rectum with CHMP4A Polyclonal Antibody (Product # PA5-117867, 1:100 dilution, formalin-fixed paraffin embedded sections).

CHMP4A Antibody in Immunoprecipitation (IP)

CHMP4A Antibody in Immunohistochemistry (IHC)

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Product Details

PA5-117867

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunoprecipitation (IP)

1-5 µL/mg of lysate

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived Human CHMP4A fragment

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

AB_2902475

Target Information

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A novel association of pyroptosis-related gene signature with the prognosis of hepatocellular carcinoma.

Frontiers in oncology

Li Y,Li Y,Zhang X,Duan X,Feng H,Yu Z,Gao Y

PA5-117867 was used in Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot to show that the three-PRG signature act as independent factor to predict the prognosis of HCC patients.

Sat Oct 22 00:00:00 UTC 2022