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NeoBiotechnologies
CDw17 (Lactosylceramide or LacCer) Monoclonal Antibody (HuLy-m13)
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Product Details
MSM1-1088-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
HuLy-m13
Immunogen
β-2 Microglobulin associated proteins from a detergent lysate of human PBL
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CDw17, also known as Lactosylceramide (LacCer) or CD17, is a glycosphingolipid present on the surface of various cell types, including leukocytes, erythrocytes, and endothelial cells. It serves as a significant component of the cell membrane, involved in cell-cell interactions, cell adhesion, and signal transduction. Lactosylceramide is synthesized by the enzyme B-1,4-galactosyltransferase, which adds a galactose molecule to glucosylceramide. It acts as a precursor for more complex glycosphingolipids, playing critical roles in numerous physiological processes and immune responses. CDw17 is implicated in several pathological conditions, including atherosclerosis, cancer, and inflammatory diseases. In cancer, CDw17 acts as a mediator for tumor cell adhesion, invasion, and metastasis, making it a potential target for therapeutic intervention. Additionally, due to its role in the immune system, modulation of Lactosylceramide levels can influence immune cell functions and inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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