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          • Primary Antibodies ›
          • CDKN2B (Isoform 2) Antibodies

          Invitrogen

          CDKN2B (Isoform 2) Polyclonal Antibody

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          Cite CDKN2B (Isoform 2) Polyclonal Antibody

          • Antibody Testing Data (1)
          CDKN2B (Isoform 2) Antibody in Western Blot (WB)
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          CDKN2B (Isoform 2) Antibody in Western Blot (WB)
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          FIGURE: 1 / 1

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          CDKN2B (Isoform 2) Antibody (PA5-142832) in WB

          Western Blot analysis of CDKN2B (Isoform 2) in Human Gastrointestinal cancer lysate (35 µg protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide using CDKN2B (Isoform 2) Polyclonal Antibody (Product # PA5-142832) at 1 µg/mL incubated for 1 hour. Detected by chemiluminescence. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          CDKN2B (Isoform 2) Antibody in Western Blot (WB)

          Product Details

          PA5-142832

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-3 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Goat / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide with sequence C-RQGARERGARP.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Ammonium sulfate precipitation

          Storage buffer

          TBS, pH 7.3, with 0.5% BSA

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Wet ice

          RRID

          AB_2933475

          Product Specific Information

          Additional Information: This antibody is expected to recognize isoform 2 (NP_511042.1) only.

          This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

          Target Information

          This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: CDK inhibitory protein; CDK4B inhibitor; Cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; MTS-2; Multiple tumor suppressor 2; p14-INK4b; p14_CDK inhibitor; p14_INK4B; p15 CDK inhibitor; p15-INK4b; p15_INK4B; p15INK4B

          View more View less

          Gene Aliases: CDK4I; CDKN2B; INK4B; MTS2; P15; p15INK4b; TP15

          View more View less

          UniProt ID: (Human) P42772

          View more View less

          Entrez Gene ID: (Human) 1030

          View more View less

          Function(s)
          cyclin-dependent protein serine/threonine kinase inhibitor activity protein binding protein kinase binding
          Process(es)
          regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle cell cycle arrest mitotic cell cycle checkpoint negative regulation of cell proliferation megakaryocyte differentiation positive regulation of transforming growth factor beta receptor signaling pathway cellular response to extracellular stimulus cellular response to nutrient negative regulation of phosphorylation positive regulation of transcription from RNA polymerase II promoter spleen development negative regulation of epithelial cell proliferation negative regulation of protein serine/threonine kinase activity negative regulation of G1/S transition of mitotic cell cycle
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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