Proteintech

CDCA7 Polyclonal Antibody

CDCA7 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 5

CDCA7 Antibody (15249-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 15249-1-AP (CDCA7 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

CDCA7 Antibody in Immunoprecipitation (IP)

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Product Details

15249-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

1:300

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CDCA7 Fusion Protein Ag4297 (1-371 aa encoded by BC027966)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDARRVPQK DLRVKKNLKK FRYVKLISME TSSSSDDSCD SFASDNFANT RLQSVREGCR TRSQCRHSGP LRVAMKFPAR STRGATNKKA ESRQPSENSV TDSNSDSEDE SGMNFLEKRA LNIKQNKAML AKLMSELESF PGSFRGRHPL PGSDSQSRRP RRRTFPGVAS RRNPERRARP LTRSRSRILG SLDALPMEEE EEEDKYMLVR KRKTVDGYMN EDDLPRSRRS RSSVTLPHII RPVEEITEEE LENVCSNSRE KIYNRSLGST CHQCRQKTID TKTNCRNPDC WGVRGQFCGP CLRNRYGEEV RDALLDPNWH CPPCRGICNC SFCRQRDGRC ATGVLVYLAK YHGFGNVHAY LKSLKQEFEM QA (1-371 aa encoded by BC027966)

Target Information

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation.

Bioorganic chemistry

Chen J,Lin X,He J,Liu J,He J,Tao C,Wang Q

Tue Nov 01 00:00:00 UTC 2022

TET2-BCLAF1 transcription repression complex epigenetically regulates the expression of colorectal cancer gene Ascl2 via methylation of its promoter.

The Journal of biological chemistry

Shang Y,Jiang T,Ran L,Hu W,Wu Y,Ye J,Peng Z,Chen L,Wang R

Fri Jul 01 00:00:00 UTC 2022

Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.

The Journal of experimental medicine

Helfricht A,Thijssen PE,Rother MB,Shah RG,Du L,Takada S,Rogier M,Moritz J,IJspeert H,Stoepker C,van Ostaijen-Ten Dam MM,Heyer V,Luijsterburg MS,de Groot A,Jak R,Grootaers G,Wang J,Rao P,Vertegaal ACO,van Tol MJD,Pan-Hammarström Q,Reina-San-Martin B,Shah GM,van der Burg M,van der Maarel SM,van Attikum H

Mon Nov 02 00:00:00 UTC 2020

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

bioRxiv : the preprint server for biology

Wang L,Muneer A,Xie L,Zhang F,Wu B,Mei L,Lenarcic EM,Feng EH,Song J,Xiong Y,Yu X,Wang C,Gheorghe C,Torralba K,Cook JG,Wan YY,Moorman NJ,Song H,Jin J,Chen X

Mon Nov 16 00:00:00 UTC 2020

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Jenness C,Giunta S,Müller MM,Kimura H,Muir TW,Funabiki H

Tue Jan 30 00:00:00 UTC 2018

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.

Proceedings of the National Academy of Sciences of the United States of America

Jenness C,Giunta S,Müller MM,Kimura H,Muir TW,Funabiki H

Tue Jan 30 00:00:00 UTC 2018

Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors.

BMC neuroscience

Huang YT,Mason JO,Price DJ

Mon Jun 05 00:00:00 UTC 2017

Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors.

BMC neuroscience

Huang YT,Mason JO,Price DJ

Mon Jun 05 00:00:00 UTC 2017

Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.

Human molecular genetics

Wu H,Thijssen PE,de Klerk E,Vonk KK,Wang J,den Hamer B,Aytekin C,van der Maarel SM,Daxinger L

Thu Sep 15 00:00:00 UTC 2016

Converging disease genes in ICF syndrome: ZBTB24 controls expression of CDCA7 in mammals.

Human molecular genetics

Wu H,Thijssen PE,de Klerk E,Vonk KK,Wang J,den Hamer B,Aytekin C,van der Maarel SM,Daxinger L

Thu Sep 15 00:00:00 UTC 2016

Transmissible gastroenteritis virus (TGEV) infection alters the expression of cellular microRNA species that affect transcription of TGEV gene 7.

International journal of biological sciences

Song X,Zhao X,Huang Y,Xiang H,Zhang W,Tong D

Mon May 02 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: c-Myc target JPO1; Cell division cycle-associated protein 7; Protein JPO1

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Gene Aliases: 2310021G01Rik; AU044109; CDCA7; ICF3; JPO1

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UniProt ID: (Human) Q9BWT1, (Rat) Q4KM91, (Mouse) Q9D0M2

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Entrez Gene ID: (Human) 83879, (Rat) 311742, (Mouse) 66953

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Function(s)

molecular_function

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process regulation of cell proliferation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CDCA7 Polyclonal Antibody

CDCA7 Antibody (15249-1-AP) in ICC/IF

Product Details

15249-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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