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Invitrogen
CD72 Polyclonal Antibody
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FIGURE: 1 / 1
CD72 Antibody (PA5-97292) in WB
Western blot analysis of CD72 in Daudi cells. Samples were incubated with CD72 Polyclonal antibody (Product # PA5-97292) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-97292
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 120-359 of human CD72 (NP_0017731)
Conjugate
Form
Liquid
Concentration
1.28 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2809094
Product Specific Information
Immunogen sequence: QVSQQLQQTN RVLEVTNSSL RQQLRLKITQ LGQSAEDLQG SRRELAQSQE ALQVEQRAHQ AAEGQLQACQ ADRQKTKETL QSEEQQRRAL EQKLSNMENR LKPFFTCGSA DTCCPSGWIM HQKSCFYISL TSKNWQESQK QCETLSSKLA TFSEIYPQSH SYYFLNSLLP NGGSGNSYWT GLSSNKDWKL TDDTQRTRTY AQSSKCNKVH KTWSWWTLES ESCRSSLPYI CEMTAFRFPD; Positive Samples: B-cell, Mouse liver, Mouse kidney, Rat liver, Rat kidney; Cellular Location: Membrane, Single-pass type II membrane protein
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell differentiation antigen CD72; CD72; CD72 antigen; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
Gene Aliases: CD72; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2; LYB2
UniProt ID: (Human) P21854, (Mouse) P21855
Entrez Gene ID: (Human) 971, (Rat) 313498, (Mouse) 12517
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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