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Invitrogen
CD72 Polyclonal Antibody
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Product Details
PA5-102948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CD72(Accession P21854), corresponding to amino acid residues R176-C226.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852324
Product Specific Information
Antibody detects endogenous levels of total CD72.
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell differentiation antigen CD72; CD72; CD72 antigen; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
Gene Aliases: CD72; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2; LYB2
UniProt ID: (Human) P21854, (Mouse) P21855
Entrez Gene ID: (Human) 971, (Mouse) 12517
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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