Proteintech

CD4 Polyclonal Antibody

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CD4 Antibody (19068-1-AP) in WB

Mouse thymus tissue were subjected to SDS PAGE followed by western blot with 19068-1-AP (CD4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

CD4 Antibody in Immunoprecipitation (IP)

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Product Details

19068-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CD4 Fusion Protein Ag13616 (419-458 aa encoded by BC025782)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: CVRCRHRRR QAERMSQIKR LLSEKKTCQC PHRFQKTCSP I (419-458 aa encoded by BC025782)

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Natural killer cells strengthen antitumor activity of cisplatin by immunomodulation and ameliorate cisplatin-induced side effects.

International urology and nephrology

Wang Z,Yang Z,Qu C,Li J,Wang X

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Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein.

Virologica Sinica

Shen W,Liu C,Hu Y,Ding Q,Feng J,Liu Z,Kong X

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Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.

Frontiers in immunology

Deng Y,Guo K,Tang Z,Feng Y,Cai S,Ye J,Xi Y,Li J,Liu R,Cai C,Tan Z,Zhang Y,Han Z,Zeng G,Zhong W

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A Toxin-Conjugated Recombinant Protein Targeting gp120 and gp41 for Inactivating HIV-1 Virions and Killing Latency-Reversing Agent-Reactivated Latent Cells.

mBio

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Tue Feb 22 00:00:00 UTC 2022

Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma.

Frontiers in genetics

Zhang Z,Shang J,Dai Z,Yao Y,Shi Y,Zhong D,Liang Y,Lai C,Yang Q,Feng T,Huang X

Tue May 24 00:00:00 UTC 2022

Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation.

ACS applied materials & interfaces

Xu N,Hu A,Pu X,Li J,Wang X,Wang J,Huang Z,Liao X,Yin G

Wed Apr 13 00:00:00 UTC 2022

Genistein suppresses allergic contact dermatitis through regulating the MAP2K2/ERK pathway.

Food & function

Xu J,Xiong H,Zhao Z,Luo M,Ju Y,Yang G,Mei Z

Fri May 21 00:00:00 UTC 2021

Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.

Journal of controlled release : official journal of the Controlled Release Society

Jin F,Qi J,Liu D,You Y,Shu G,Du Y,Wang J,Xu X,Ying X,Ji J,Du Y

Fri Sep 10 00:00:00 UTC 2021

Human Milk Oligosaccharide 2'-Fucosyllactose Induces Neuroprotection from Intracerebral Hemorrhage Stroke.

International journal of molecular sciences

Hung TW,Wu KJ,Wang YS,Bae EK,Song Y,Yoon J,Yu SJ

Mon Sep 13 00:00:00 UTC 2021

Naltrexone is neuroprotective against traumatic brain injury in mu opioid receptor knockout mice.

CNS neuroscience & therapeutics

Wang YS,Hung TW,Bae EK,Wu KJ,Hsieh W,Yu SJ

Thu Jul 01 00:00:00 UTC 2021

Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease.

Experimental neurology

Haque A,Samantaray S,Knaryan VH,Capone M,Hossain A,Matzelle D,Chandran R,Shields DC,Farrand AQ,Boger HA,Banik NL

Sat Aug 01 00:00:00 UTC 2020

Rebamipide ophthalmic solution modulates the ratio of T helper cell 17/regulatory T cells in dry eye disease mice.

Molecular medicine reports

Fu R,Jiang Y,Zhou J,Zhang J

Wed May 01 00:00:00 UTC 2019

Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells.

Oncology letters

Lei C,Ren D,Fu M,Sun C,Ren H,Pan Q,Li Y

Mon Apr 01 00:00:00 UTC 2019

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer.

Molecular medicine (Cambridge, Mass.)

Liu Q,Guo L,Zhang S,Wang J,Lin X,Gao F

Sat Sep 14 00:00:00 UTC 2019

The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.

Cancer medicine

Cao Z,Ji J,Zhang C,Wang F,Xu H,Yu Y,Sun Y

Fri Mar 01 00:00:00 UTC 2019

The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Gao W,Zhang L,Wang X,Yu L,Wang C,Gong Y

Mon Oct 01 00:00:00 UTC 2018

The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Gao W,Zhang L,Wang X,Yu L,Wang C,Gong Y

Mon Oct 01 00:00:00 UTC 2018

PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.

Journal of hematology & oncology

Zheng B,Ren T,Huang Y,Sun K,Wang S,Bao X,Liu K,Guo W

Tue Feb 06 00:00:00 UTC 2018

PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse.

Journal of hematology & oncology

Zheng B,Ren T,Huang Y,Sun K,Wang S,Bao X,Liu K,Guo W

Tue Feb 06 00:00:00 UTC 2018

CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis.

Cell death & disease

Liu QC,Chen F,Wu CY,Gao F,Zhuang ZH,Chen JT,Cai B,Zhang T,Guo L,Lin LQ,Zhao CF,Lin XH

Thu Feb 02 00:00:00 UTC 2017

CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis.

Cell death & disease

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Adropin deficiency worsens HFD-induced metabolic defects.

Cell death & disease

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Bioinformatics

Protein Aliases: CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; cd4a; fCD4; Leu-3; lymphocyte antigen CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); W3/25 antigen

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Gene Aliases: CD4; CD4mut; L3T4; Ly-4; p55; W3/25

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UniProt ID: (Human) P01730, (Rat) P05540, (Mouse) P06332

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Entrez Gene ID: (Pig) 404704, (Human) 920, (Rat) 24932, (Mouse) 12504

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Function(s)

virus receptor activity glycoprotein binding receptor activity transmembrane signaling receptor activity extracellular matrix structural constituent protein binding zinc ion binding coreceptor activity immunoglobulin binding enzyme binding protein kinase binding MHC class II protein binding protein homodimerization activity protein tyrosine kinase binding

Process(es)

cytokine production induction by virus of host cell-cell fusion immune response cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation immune system process cell adhesion adaptive immune response signal transduction enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol fusion of virus membrane with host plasma membrane entry into host cell T cell costimulation response to estradiol response to vitamin D helper T cell enhancement of adaptive immune response positive regulation of T cell proliferation positive regulation of interleukin-2 biosynthetic process regulation of defense response to virus by virus T cell receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD4 Polyclonal Antibody

CD4 Antibody (19068-1-AP) in WB

Product Details

19068-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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