Invitrogen

CD39 Polyclonal Antibody

CD39 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD39 Antibody (PA5-82495) in IHC (P)

Immunohistochemical analysis of CD39 in human placenta using CD39 Polyclonal Antibody (Product # PA5-82495) shows strong cytoplasmic positivity in trophoblastic cells.

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CD39 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of CD39 demonstrates antibody specificity. Immunohistochemical analysis of CD39 using anti-CD39 Polyclonal Antibody (Product #PA5-82495), shows significant staining of CD39 in smooth muscle and shows minimal or weak staining in skeletal muscle tissues. The relative expression levels of CD39 within each tissue is shown using RNA-Seq. {RE}

Product Details

PA5-82495

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ENTPD1

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_2789653

Product Specific Information

Immunogen sequence: GVVHQVEECR VKGPGISKFV QKVNEIGIYL TDCMERAREV IPRSQHQETP VYLGATAGMR LLRMESEELA DRVLDVVERS LSNYPFDFQG ARIITGQEEG AYGWITINYL LGKFSQKTRW FS

Target Information

CD39 is an integral membrane protein characterized by two transmembrane domains and forms a homotetramer structure. It is recognized as the most prominent ectoenzyme within the immune system, primarily functioning to remove toxic extracellular ATP by converting it into ADP or AMP. CD39 works in conjunction with CD73 to hydrolyze ATP and is well characterized on Langerhans cells. Originally identified on activated lymphocytes, CD39 is expressed on a variety of immune cells, including peripheral blood B cells, monocytes, and T cell clones. It is also found on a subset of T cells, B cells, and dendritic cells, with weaker expression observed on monocytes and granulocytes. The CD39 cell surface antigen is a 70-100kD molecule, and its expression is induced on T cells and increases on B cells as a late activation antigen. CD39 possesses intrinsic ecto-ATPase activity, playing a crucial role in modulating extracellular nucleotide levels and contributing to immune regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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