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Fabgennix
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Ccr4-Not complex is of interest to many groups because it regulates transcription, decay of mRNA, translation and even protein degradation. Ccr4-Not is a nine-subunit protein complex that is conserved in sequence and function throughout the eukaryotic kingdom. It has been reported to solely regulate transcription, it is now clear that it has much broader roles in gene regulation, such as in mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation. The yeast Ccr4-Not complex contains nine conserved subunits: Not1, Not2, Not3, Not4/Mot2, Not5, Caf130, Caf40, Pop2/Caf1, and Ccr4.
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