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Invitrogen
CCDC127 Polyclonal Antibody
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Product Details
PA5-113214
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Coiled-coil domain-containing protein 127 protein (1-260AA)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2867948
Target Information
CCDC127 (Coiled-Coil Domain-Containing 127) is a gene that has been identified as a key regulator of lipid droplet (LD) homeostasis by enhancing the mitochondria-ER contact sites (MERCS). This gene encodes a protein with coiled-coil domains, which facilitate interactions with other proteins and cellular structures. CCDC127 plays a critical role in the formation and maintenance of LDs, which are essential organelles for storing neutral lipids and are involved in lipid metabolism and energy homeostasis. Knockdown and overexpression studies in HeLa cells have shown that CCDC127 positively regulates LD abundance, suggesting its importance in cellular lipid management. Additionally, it has been observed that CCDC127 impacts adipose differentiation, indicating its broader role in lipid biology and potential implications in metabolic diseases. The ability of CCDC127 to modulate MERCS highlights its significance in cellular lipid dynamics and organelle communication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 127
Gene Aliases: 0610011N22Rik; 5430420E17Rik; A430066A18; AI256405; AW050060; C130002N06; CCDC127
UniProt ID: (Human) Q96BQ5, (Mouse) Q3TC33
Entrez Gene ID: (Human) 133957, (Mouse) 67433
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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