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Invitrogen
C1orf74 Polyclonal Antibody
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Product Details
PA5-55879
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human C1orf74. Recombinant protein control fragment (Product #RP-94407).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638947
Product Specific Information
Immunogen sequence: LLGYPVPYTF HLNQGDDNCL ALTPLRVFTA RISWLLGQPP ILLYSFSVPE SLFPGLRDIL NTWEKDLRTR FRTQNDFADL
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 76%.
Target Information
C1orf74, also known as URCL4, is located on chromosome 1q32.2 and encodes a previously uncharacterized protein. Recent studies have revealed that C1orf74 is significantly up-regulated in various cancers, including cervical cancer and lung adenocarcinoma. The overexpression of C1orf74 is associated with poor prognosis, indicating its potential role in tumor progression and proliferation. Mechanistically, C1orf74 has been shown to positively regulate the EGFR/AKT/mTORC1 signaling pathway, which is crucial for cell growth and survival. Knockdown studies have demonstrated that reducing C1orf74 expression inhibits cancer cell growth, highlighting it as a potential therapeutic target. Additionally, C1orf74's role in immune cell infiltration suggests it may influence the tumor immune microenvironment, further implicating its importance in cancer biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: up-regulated in lung cancer 4; UPF0739 protein C1orf74
Gene Aliases: C1orf74; URLC4
UniProt ID: (Human) Q96LT6
Entrez Gene ID: (Human) 148304
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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