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          • Primary Antibodies ›
          • Blood Group H antigen Antibodies

          Invitrogen

          Blood Group Antigen H (O) Type 1 Monoclonal Antibody (17-206), Alexa Fluor™ 488, eBioscience™

          View all (6) Blood Group H antigen antibodies

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          Cite Blood Group Antigen H (O) Type 1 Monoclonal Antibody (17-206), Alexa Fluor™ 488, eBioscience™

          • Antibody Testing Data (1)
          Blood Group Antigen H (O) Type 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Blood Group Antigen H (O) Type 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          Blood Group Antigen H (O) Type 1 Antibody (53-9810-82) in IHC (P)

          Immunohistochemistry on formalin-fixed paraffin embedded human kidney medulla using 10 µg/mL of Anti-Human Blood Group Antigen H (O) Type 1 Antigen Alexa Fluor® 488. Nuclei are counterstained with DAPI. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Blood Group Antigen H (O) Type 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

          Product Details

          53-9810-82

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          10 µg/mL
          -

          Immunohistochemistry (Frozen) (IHC (F))

          10 µg/mL
          -

          Immunocytochemistry (ICC/IF)

          Assay-Dependent
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG3

          Class

          Monoclonal

          Type

          Antibody

          Clone

          17-206

          Conjugate

          Alexa Fluor™ 488 Alexa Fluor™ 488 Alexa Fluor™ 488
          • Unconjugated
          • Biotin 
          • Request custom conjugation

          Excitation/Emission Max

          499/520 nm View spectra spectra

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.2

          Contains

          0.09% sodium azide

          Storage conditions

          4°C, store in dark, DO NOT FREEZE!

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_11218689

          Product Specific Information

          Description: The monoclonal antibody 17-206 recognizes the human blood group antigen H (O) type 1, a subtype primarily found in epithelial and secretory cells. The precursor H antigen is modified by addition of saccharides to carbohydrate chains of proteins and lipids on erythrocytes and epithelial cells. The type, attachment, location, and sequence of saccharides determines the blood group antigen subtype and is mediated by multiple glycosyl transferases. Depending on ABO blood type, the H antigen is converted into either the A antigen, B antigen, both the A and B antigen, or left unconverted (O antigen). Evidence that the blood group antigen H is not expressed in tumor cells and that the level correlates with disease progression suggests that the blood group antigen H may be involved in cell proliferation, cell adhesion, and angiogenesis, although its exact function remains to be determined. The 17-206 antibody does not recognize blood group antigen H (O) type 2.

          Applications Reported: This 17-206 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.

          Applications Tested: This 17-206 antibody has been tested by immunohistochemistry on formalin-fixed paraffin embedded human tissue using either low or high pH antigen retrieval at less than or equal to 10 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

          Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.

          Filtration: 0.2 µm post-manufacturing filtered.

          Target Information

          The H antigen is a precursor to the ABO blood group antigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs by complement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from other hh donors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains three exons that span more than 5 kb of genomic DNA, and encodes the fucosyltransferase that produces the H antigen on RBCs. The H antigen is a carbohydrate sequence with carbohydrates linked mainly to protein (with a minor fraction attached to ceramide moiety).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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