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Invitrogen
BABAM1 Polyclonal Antibody
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FIGURE: 1 / 2
BABAM1 Antibody (PA5-85503) in WB
Western blot analysis of BABAM1 in A) 293T whole cell lysate, B) whole cell lysate of human C19orf62-transfected 293T cells using BABAM1 polyclonal antibody (Product # PA5-85503) using 30 µg of sample at a dilution of 1:10000. Prior to incubation with primary antibody, the sample was separated on 10% SDS-PAGE.
Product Details
PA5-85503
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human HSPC142.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792643
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (95%), Rat (91%), Rhesus Monkey (98%), Bovine (95%).
Positive Control: human C19orf62-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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