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Invitrogen
B7-H6 Polyclonal Antibody
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Product Details
PA5-54991
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NCR3LG1
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644528
Product Specific Information
Immunogen sequence: TPLNDNVTIF CNIFYSQPLN ITSMGITWFW KSLTFDKEVK VFEFFGDHQE AFRPGAIVSP WRLKSGDASL RLPGIQLEEA GEYRCEVVVT PLKAQGTVQL EVVASPASRL LLDQVGMKEN EDKYMCESSG FY
Highest antigen sequence identity to the following orthologs: Mouse - 27%, Rat - 28%.
Target Information
B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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