Product References
The mechanosensitive Piezo1 channels contribute to the arterial medial calcification.
Frontiers in physiology
Szabó L,Balogh N,Tóth A,Angyal Á,Gönczi M,Csiki DM,Tóth C,Balatoni I,Jeney V,Csernoch L,Dienes B
PA5-16697 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate the pivotal role of Piezo1 channels in arterial medial calcification.
Tue Nov 29 00:00:00 UTC 2022
Data-Driven Kidney Transplant Phenotyping as a Histology-Independent Framework for Biomarker Discovery.
Journal of the American Society of Nephrology : JASN
Buscher K,Heitplatz B,van Marck V,Song J,Loismann S,Rixen R,Hüchtmann B,Kurian S,Ehinger E,Wolf D,Ley K,Pavenstädt H,Reuter S
PA5-16697 was used in Immunohistochemistry-immunofluorescence to provide a comprehensive, data-driven atlas of human kidney transplant phenotypes and demonstrates its utility to identify novel clinical biomarkers.
Sun Aug 01 00:00:00 UTC 2021
A novel mouse model to evaluate neuropeptide Y-mediated melanocyte pathology.
Experimental dermatology
Anderson ZT,Mehl J,Corder KM,Dobrunz LE,Harris ML
PA5-16697 was used in Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that supraphysiological levels of neuropeptide Y (NPY) in the skin can induce melanocyte dysfunction, thus identifying this mouse line as a novel model to study NPY-mediated melanocyte pathology.
Wed Dec 01 00:00:00 UTC 2021
Protective mechanism of SIRT1 on Hcy-induced atrial fibrosis mediated by TRPC3.
Journal of cellular and molecular medicine
Han L,Tang Y,Li S,Wu Y,Chen X,Wu Q,Hong K,Li J
PA5-16697 was used in Immunohistochemistry to show that atrial fibrosis is mediated by the relationship between canonical transient receptor potential 3 (TRPC3) channels and sirtuin type 1 (SIRT1) under the stimulation of Hcy.
Wed Jan 01 00:00:00 UTC 2020
Diminished Vitamin D Receptor Protein Levels in Crohn's Disease Fibroblasts: Effects of Vitamin D.
Nutrients
Gisbert-Ferrándiz L,Cosín-Roger J,Hernández C,Macias-Ceja DC,Ortiz-Masiá D,Salvador P,Esplugues JV,Hinojosa J,Navarro F,Calatayud S,Barrachina MD
PA5-16697 was used in Western Blotting to demonstrate that Vitamin D receptor is diminished in fibroblasts isolated from damaged tissue of Crohn's Disease patients, and treatment with Vitamin D increased Vitamin D receptor levels and prevented the enhanced migration detected in these cells.
Wed Apr 01 00:00:00 UTC 2020
Diminished Vitamin D Receptor Protein Levels in Crohn's Disease Fibroblasts: Effects of Vitamin D.
Nutrients
Gisbert-Ferrándiz L,Cosín-Roger J,Hernández C,Macias-Ceja DC,Ortiz-Masiá D,Salvador P,Esplugues JV,Hinojosa J,Navarro F,Calatayud S,Barrachina MD
PA5-16697 was used in Western Blotting to demonstrate that Vitamin D receptor is diminished in fibroblasts isolated from damaged tissue of Crohn's Disease patients, and treatment with Vitamin D increased Vitamin D receptor levels and prevented the enhanced migration detected in these cells.
Wed Apr 01 00:00:00 UTC 2020
ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.
Science advances
Kuninty PR,Bansal R,De Geus SWL,Mardhian DF,Schnittert J,van Baarlen J,Storm G,Bijlsma MF,van Laarhoven HW,Metselaar JM,Kuppen PJK,Vahrmeijer AL,Östman A,Sier CFM,Prakash J
PA5-16697 was used in Immunohistochemistry to investigate the therapeutic potential of integrin α5 (ITGA5) receptor in the PDAC stroma.
Sun Sep 01 00:00:00 UTC 2019
Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4.
Scientific reports
Rodriguez LR,Emblom-Callahan M,Chhina M,Bui S,Aljeburry B,Tran LH,Novak R,Lemma M,Nathan SD,Grant GM
PA5-16697 was used in Immunocytochemistry to analyse pulmonary fibroblasts from idiopathic pulmonary fibrosis patients as they transition through cell culture to identify altered cellular processes.
Mon Mar 05 00:00:00 UTC 2018
Human liver regeneration in advanced cirrhosis is organized by the portal tree.
Journal of hepatology
Dezső K,Rókusz A,Bugyik E,Szücs A,Szuák A,Dorogi B,Kiss M,Nemeskéri Á,Nagy P,Paku S
PA516697 was used in immunohistochemistry - paraffin section to examine the vascular alterations in the areas of parenchymal extinction
Sat Apr 01 00:00:00 UTC 2017
Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells.
Biomarker insights
de Geus SW,Baart VM,Boonstra MC,Kuppen PJ,Prevoo HA,Mazar AP,Bonsing BA,Morreau H,van de Velde CJ,Vahrmeijer AL,Sier CF
PA5-16697 was used in Immunohistochemistry to assess the prognostic value of urokinase plasminogen activator receptor expression in neoplastic and stromal cells of patients with pancreatic adenocarcinoma.
Wed Sep 30 00:00:00 UTC 2020
Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells.
Biomarker insights
de Geus SW,Baart VM,Boonstra MC,Kuppen PJ,Prevoo HA,Mazar AP,Bonsing BA,Morreau H,van de Velde CJ,Vahrmeijer AL,Sier CF
PA5-16697 was used in Immunohistochemistry to assess the prognostic value of urokinase plasminogen activator receptor expression in neoplastic and stromal cells of patients with pancreatic adenocarcinoma.
Wed Sep 30 00:00:00 UTC 2020
Microfabricated blood vessels undergo neoangiogenesis.
Biomaterials
DiVito KA,Daniele MA,Roberts SA,Ligler FS,Adams AA
PA5-16697 was used in Immunocytochemistry-immunofluorescence to fabricate free-standing, small diameter blood vessels with organized cell layers that recapitulate normal biological functionality are fabricated using microfluidic technology.
Fri Sep 01 00:00:00 UTC 2017
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
Nature
Koren S,Reavie L,Couto JP,De Silva D,Stadler MB,Roloff T,Britschgi A,Eichlisberger T,Kohler H,Aina O,Cardiff RD,Bentires-Alj M
PA5-16697 was used in western blot to elucidate the potential of PIK3CA to induce multipotency during tumorigenesis in the mammary gland.
Thu Sep 03 00:00:00 UTC 2015
Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function.
PloS one
Kleinhenz JM,Murphy TC,Pokutta-Paskaleva AP,Gleason RL,Lyle AN,Taylor WR,Blount MA,Cheng J,Yang Q,Sutliff RL,Hart CM
PA5-16697 was used in western blot to learn about disruption of vascular wall structure and function by smooth muscle-targeted overexpression of peroxisome proliferator activated receptor-gamma
Tue Jun 07 00:00:00 UTC 2016
Vascular Smooth Muscle Cells Stimulate Platelets and Facilitate Thrombus Formation through Platelet CLEC-2: Implications in Atherothrombosis.
PloS one
Inoue O,Hokamura K,Shirai T,Osada M,Tsukiji N,Hatakeyama K,Umemura K,Asada Y,Suzuki-Inoue K,Ozaki Y
PA5-16697 was used in immunohistochemistry - frozen section to study platelet CLEC-2 and vascular smooth muscle cells that stimulate platelets and facilitate thrombus formation and implications in atherothrombosis
Tue May 31 00:00:00 UTC 2016
Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis.
Cancer research
Ostapoff KT,Cenik BK,Wang M,Ye R,Xu X,Nugent D,Hagopian MM,Topalovski M,Rivera LB,Carroll KD,Brekken RA
PA5-16697 was used in immunohistochemistry - paraffin section to analyze promotion of a differentiated tumor cell phenotype and inhibition of pancreatic cancer metastasis by neutralizing murine TGF-betaR2
Mon Sep 15 00:00:00 UTC 2014
Solitary tumours associated with Jaagsiekte retrovirus in sheep are heterogeneous and contain cells expressing markers identifying progenitor cells in lung repair.
Journal of comparative pathology
De las Heras M,de Martino A,Borobia M,Ortín A,Álvarez R,Borderías L,Giménez-Más JA
PA5-16697 was used in immunohistochemistry to study the heterogeneity and the presence of lung repair progenitor cells in Jaagsiekte retrovirus-associated solitary tumors in sheep
Tue Nov 18 00:00:00 UTC 2014
Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model.
PloS one
Alrifai M,Marsh LM,Dicke T,Kılıç A,Conrad ML,Renz H,Garn H
PA5-16697 was used in immunohistochemistry to study airway remodeling dynamics and the effects of inhaled corticosteroid therapy in a murine model of asthma
Wed Oct 29 00:00:00 UTC 2014
The cAMP effector EPAC activates Elk1 transcription factor in prostate smooth muscle, and is a minor regulator of α1-adrenergic contraction.
Journal of biomedical science
Hennenberg M,Strittmatter F,Schmetkamp H,Rutz B,Walther S,Stief CG,Gratzke C
PA5-16697 was used in immunohistochemistry to study the modulation of the Elk1 transcription factor by EPAC in prostate smooth muscle
Tue Jul 02 00:00:00 UTC 2013
Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma.
Cancer
Cao Y,Zhang ZL,Zhou M,Elson P,Rini B,Aydin H,Feenstra K,Tan MH,Berghuis B,Tabbey R,Resau JH,Zhou FJ,Teh BT,Qian CN
PA5-16697 was used in immunohistochemistry to study the prognostic significance of pericyte coverage of differentiated tumor microvessels in clear cell renal cell carcinoma
Tue Jan 15 00:00:00 UTC 2013
Smooth muscle cell transplantation improves bladder contractile function in streptozocin-induced diabetic rats.
Cytotherapy
Gopinath C,Ponsaerts P,Fransen E,Boeykens N,Pauwels P,Wyndaele JJ
PA5-16697 was used in immunocytochemistry and immunohistochemistry - frozen section to discuss factors that contribute to defects observed in diabetic bladders
Mon Jul 01 00:00:00 UTC 2013
The impact of KRAS mutations on VEGF-A production and tumour vascular network.
BMC cancer
Figueras A,Arbos MA,Quiles MT,Viñals F,Germà JR,Capellà G
PA5-16697 was used in immunohistochemistry to study the differential effects on the production of VEGF-A and tumor vasculature development of codon 12 and codon 13 KRAS mutations
Mon Mar 18 00:00:00 UTC 2013
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.
Nature
Krimpenfort P,Song JY,Proost N,Zevenhoven J,Jonkers J,Berns A
PA5-16697 was used in immunohistochemistry to study the suppression of p53-deficient mammary tumor metastasis by DCC
Wed Feb 22 00:00:00 UTC 2012
Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats.
Clinical science (London, England : 1979)
Imarisio C,Alchera E,Sutti S,Valente G,Boccafoschi F,Albano E,Carini R
PA5-16697 was used in immunohistochemistry to study the molecular mechanisms underlying the protection against lipotoxicity and non-hepatic steatosis of adenosine A2a receptor activation
Sat Sep 01 00:00:00 UTC 2012
Recruitment of podoplanin positive cancer-associated fibroblasts in metastatic lymph nodes predicts poor prognosis in pathological N2 stage III lung adenocarcinoma.
Annals of surgical oncology
Neri S,Ishii G,Taira T,Hishida T,Yoshida J,Nishimura M,Nagai K,Ochiai A
PA5-16697 was used in immunohistochemistry to study the prognostic significance podoplanin-expressing positive cancer-associated fibroblasts in patients with pathological N2 stage III lung adenocarcinoma
Thu Nov 01 00:00:00 UTC 2012
Expression of NOS and VEGF in feline mammary tumours and their correlation with angiogenesis.
Veterinary journal (London, England : 1997)
Islam MS,Matsumoto M,Hidaka R,Miyoshi N,Yasuda N
PA5-16697 was used in immunohistochemistry to study the expression of eNOS, iNOS and VEGF and their correlation with angiogenesis in feline mammary tumors
Fri Jun 01 00:00:00 UTC 2012
Giant cell tumor of bonelike lesion in a Trp53 mutant mouse.
Toxicologic pathology
Radaelli E,Rustighi A,Scanziani E
PA5-16697 was used in immunocytochemistry and immunohistochemistry to report on a case of giant cell tumor of bonelike lesion in a Trp53 mutant mouse
Fri Jun 01 00:00:00 UTC 2012
Generation and hepatic differentiation of human iPS cells.
Methods in molecular biology (Clifton, N.J.)
Ishikawa T,Hagiwara K,Ochiya T
PA5-16697 was used in immunohistochemistry to develop a method for the generation and hepatic differentiation of human induced pluripotent stem cells
Tue Apr 03 00:00:00 UTC 2012
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Cancer research
Meyer DS,Brinkhaus H,Müller U,Müller M,Cardiff RD,Bentires-Alj M
PA5-16697 was used in immunohistochemistry to elucidate the contribution of PIK3CA H1047R to breast cancer pathogenesis.
Fri Jul 01 00:00:00 UTC 2011
