Proteintech

ARL15 Polyclonal Antibody

ARL15 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARL15 Antibody (11934-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma using 11934-1-AP (ARL15 antibody) at dilution of 1:50 (under 40x lens).

ARL15 Antibody in Immunoprecipitation (IP)

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Product Details

11934-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARL15 Fusion Protein Ag2530 (1-204 aa encoded by BC026093)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSDLRITEA FLYMDYLCFR ALCCKGPPPA RPEYDLVCIG LTGSGKTSLL SKLCSESPDN VVSTTGFSIK AVPFQNAILN VKELGGADNI RKYWSRYYQG SQGVIFVLDS ASSEDDLEAA RNELHSALQH PQLCTLPFLI LANHQDKPAA RSVQEIKKYF ELEPLARGKR WILQPCSLDD MDALKDSFSQ LINLLEEKDH EAVRM (1-204 aa encoded by BC026093)

Target Information

ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of cholera toxin. ARFs are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL15 (ADP-ribosylation factor-like 15), is a member of the ARF family of the Ras superfamily of small GTPases that are known to be involved in multiple regulatory pathways altered in human carcinogenesis. Other members of this protein family include ARL11, thought to be a tumor suppressor and may play a role in the regulation of apoptosis, ARL2 which plays an important role in microtubule dynamics and cell cycle progression, and ARL4, which may play a role in neurogenesis during embryonic development. The gene encoding ARL15 maps to chromosome 5p15 in humans. At least three isoforms of ARL15 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells.

PLoS biology

Bai Z,Feng J,Franken GAC,Al'Saadi N,Cai N,Yu AS,Lou L,Komiya Y,Hoenderop JGJ,de Baaij JHF,Yue L,Runnels LW

Wed Dec 01 00:00:00 UTC 2021

ARL15 overexpression attenuates high glucose-induced impairment of insulin signaling and oxidative stress in human umbilical vein endothelial cells.

Life sciences

Shen J,Liu M,Xu J,Sun B,Xu H,Zhang W

Fri Mar 01 00:00:00 UTC 2019

ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.

Biochemical and biophysical research communications

Zhao J,Wang M,Deng W,Zhong D,Jiang Y,Liao Y,Chen B,Zhang X

Sat May 13 00:00:00 UTC 2017

ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity.

Biochemical and biophysical research communications

Zhao J,Wang M,Deng W,Zhong D,Jiang Y,Liao Y,Chen B,Zhang X

Sat May 13 00:00:00 UTC 2017

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

PLoS genetics

Richards JB,Waterworth D,O'Rahilly S,Hivert MF,Loos RJ,Perry JR,Tanaka T,Timpson NJ,Semple RK,Soranzo N,Song K,Rocha N,Grundberg E,Dupuis J,Florez JC,Langenberg C,Prokopenko I,Saxena R,Sladek R,Aulchenko Y,Evans D,Waeber G,Erdmann J,Burnett MS,Sattar N,Devaney J,Willenborg C,Hingorani A,Witteman JC,Vollenweider P,Glaser B,Hengstenberg C,Ferrucci L,Melzer D,Stark K,Deanfield J,Winogradow J,Grassl M,Hall AS,Egan JM,Thompson JR,Ricketts SL,König IR,Reinhard W,Grundy S,Wichmann HE,Barter P,Mahley R,Kesaniemi YA,Rader DJ,Reilly MP,Epstein SE,Stewart AF,Van Duijn CM,Schunkert H,Burling K,Deloukas P,Pastinen T,Samani NJ,McPherson R,Davey Smith G,Frayling TM,Wareham NJ,Meigs JB,Mooser V,Spector TD

Tue Dec 01 00:00:00 UTC 2009

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.

PLoS genetics

Tue Dec 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: ADP-ribosylation factor like GTPase 15; ADP-ribosylation factor related protein 2; ADP-ribosylation factor-like 15; ADP-ribosylation factor-like protein 15; ADP-ribosylation factor-related protein 2; ARF-related protein 2; FLJ20051

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Gene Aliases: A430036I03; ARFRP2; ARL15; C230032K13Rik

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UniProt ID: (Human) Q9NXU5, (Mouse) Q8BGR6

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Entrez Gene ID: (Human) 54622, (Mouse) 218639, (Rat) 689079

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Function(s)

molecular_function GTP binding nucleotide binding

Process(es)

small GTPase mediated signal transduction biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARL15 Polyclonal Antibody

ARL15 Antibody (11934-1-AP) in IHC (P)

Product Details

11934-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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