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Abnova
ARHGEF2 Polyclonal Antibody, MaxPab™
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Product Details
H00009181-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARHGEF2 (ABM85604.1, 1 a.a. approximately 959 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKEAKDARYT NGHLFTTISV SGMTMCYACN KSITAKEALI CPTCNVTIHN RCKDTLANCT KVKQKQQKAA LLKNNTALQS VSLRSKTTIR ERPSSAIYPS DSFRQSLLGS RRGRSSLSLA KSVSTTNIAG HFNDESPLGL RRILSQSTDS LNMRNRTLSV ESLIDEAEVI YSELMSDFEM DEKDFAADSW SLAVDSSFLQ QHKKEVMKQQ DVIYELIQTE LHHVRTLKIM TRLFRTGMLE ELHLEPGVVQ GLFPCVDELS DIHTRFLSQL LERRRQALCP GSTRNFVIHR LGDLLISQFS GPSAEQMCKT YSEFCSRHSK ALKLYKELYA RDKRFQQFIR KVTRPAVLKR HGVQECILLV TQRITKYPLL ISRILQHSHG IEEERQDLTT ALGLVKELLS NVDEGIYQLE KGARLQEIYN RMDPRAQTPV PGKGPFGREE LLRRKLIHDG CLLWKTATGR FKDVLVLLMT DVLVFLQEKD QKYIFPTLDK PSVVSLQNLI VRDIANQEKG MFLISAAPPE MYEVHTASRD DRSTWIRVIQ QSVRTCPSRE DFPLIETEDE AYLRRIKMEL QQKDRALVEL LREKVGLFAE MTHFQAEEDG GSGMALPTLP RGLFRSESLE SPRGERLLQD AIREVEGLKD LLVGPGVELL LTPREPALPL EPDSGGNTSP GVTANGEART FNGSIELCRA DSDSSQRDRN GNQLRSPQEE ALQRLVNLYG LLHGLQAAVA QQDTLMEARF PEGPERREKL CRANSRDGEA GRAGAAPVAP EKQATELALL QRQHALLQEE LRRCRRLGEE RATEAGSLEA RLRESEQARA LLEREAEEAR RQLAALGQTE PLPAEAPWAR RPVDPRRRSL PAGDALYLSF NPPQPSRGTD RLDLPVTTRS VHRNFEDRER QELGSPEERL QDSSDPDTGS EEEGSSRLSP PHSPRDFTRM QDIPEETESR DGEAVASES
Target Information
GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. GEF-H1 may be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp547L106; DKFZp547P1516; FLJ45440; GEF-H1; Guanine nucleotide exchange factor H1; Microtubule-regulated Rho-GEF; OTTHUMP00000018855; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2
Gene Aliases: ARHGEF2; GEF; GEF-H1; GEFH1; KIAA0651; LFP40; P40
UniProt ID: (Human) Q92974
Entrez Gene ID: (Human) 9181
establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
mitotic nuclear division
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
intracellular signal transduction
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
positive regulation of NF-kappaB transcription factor activity
cell division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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