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PA1-31452 has been successfully used in Western blot applications. Detects a band around 55 - 60 kDa in mouse brain samples.
The PA1-31452 immunogen is a peptide with sequence NGVVTSIQDRYGS, from C-Terminus of the protein sequence according to NP_055385.
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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