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Immunogen sequence: SIATLERLQS FRPLPEPLTV QLLTVPGEVF PPKVKYTFFV PNDVDFSMQS SKERATTNII QPLLHAQWVL
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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