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Invitrogen
ABCA1 Monoclonal Antibody (5A1-1422)
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Product Details
MA5-28159
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
5A1-1422
Immunogen
ABCA1 transfected HeLa cells
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
4°C or -20°C if preferred
Shipping conditions
Wet ice
RRID
AB_2745136
Product Specific Information
Rat anti Mouse ABCA1 antibody, clone 5A1.1422 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1).
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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