PP2CA/PP2CB Antibodies

Target Information

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Synonyms

2310003C21Rik; 2900017D14Rik; AI427932; AU017636; FLJ42306; IA; MGC9201; MMPa-2; Mpp alpha; MPPa-1; Pp2c1; Pp2c2; PP2CA; PP2Calpha; PP2C-ALPHA; PP2CB; PP2CBETA; PP2C-beta; PP2C-beta-X; PPC2BETAX; Ppm1a; PPM1B; PPM1B protein; Pppm1a; Pppm1b; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 1A, magnesium dependent, alpha isoform; protein phosphatase 1B; protein phosphatase 1B (formerly 2C), magnesium-dependent, beta isoform; protein phosphatase 1B, magnesium dependent, beta isoform; protein phosphatase 2C alpha; protein Phosphatase 2C beta; protein phosphatase 2C isoform alpha; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase IA; Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform; Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform; Protein phosphatase type 1B (formely 2C) Mg-dependent beta isoform; Protein phosphatase type 1B (formely 2C), Mg-dependent, beta isoform; protein phosphatase, Mg2+/Mn2+ dependent 1A; protein phosphatase, Mg2+/Mn2+ dependent 1B; protein phosphatase, Mg2+/Mn2+ dependent, 1A; protein phosphatase, Mg2+/Mn2+ dependent, 1B; Ser/Thr protein phosphatase type 2C beta 2 isoform