SMU1 Proteins

Protein Information

SMU1 (suppressor of Mec8 and Unc-52 homolog), also known as BWD (brain-enriched WD), is a member of the WD-repeat SMU1 family and contains one CTLH domain, one LisH domain and six WD-repeats. SMU1 is a homolog of the C. elegans protein Smu1, a ubiquitously expressed nuclear protein that is believed to play a role in alternative splicing events of Unc-52. In mammals, SMU1 is a component of the spliceosome and appears to exhibit a conserved function, affecting the splicing of the mammalian Unc-52 homolog, namely Perlecan. Mutations in the gene encoding SMU1 may affect the function of the spliceosome.

Synonyms

2600001O03Rik; 2610203K23Rik; AB044414; AI845086; AW556129; Brain-enriched WD repeat-containing protein; brain-enriched WD-repeat protein; Bwd; DNA replication regulator and spliceosomal factor; fSAP57; functional spliceosome-associated protein 57; homolog of C. elegans smu-1; SMU1; SMU-1; smu-1 suppressor of mec-8 and unc-52 homolog; smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans); smu-1 suppressor of mec-8 and unc-52 protein homolog; suppressor of Mec and Unc defects 1 homolog; WD40 repeat-containing protein SMU1; WD40 repeat-containing protein SMU1, N-terminally processed