PAI1 Proteins

PAI1 Human recombinant proteins are validated for use in the following applications: Western Blot, Blocking Assay, ELISA and Functional Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published... PAI1 Human recombinant proteins are validated for use in the following applications: Western Blot, Blocking Assay, ELISA and Functional Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. PAI1 Protein have been referenced in 3 publications... PAI1 Human recombinant proteins are validated for use in the following applications: Western Blot, Blocking Assay, ELISA and Functional Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. PAI1 Protein have been referenced in 3 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 4 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to... PAI1 Human recombinant proteins are validated for use in the following applications: Western Blot, Blocking Assay, ELISA and Functional Assay. These proteins are expressed in E. coli. Available Product Grades: RUO. Gibco and Invitrogen proteins are some of the most frequently published proteins. PAI1 Protein have been referenced in 3 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 4 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.

Synonyms

Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; Pai1; PAI-1; PAI1 protein; PAI1A; Pai1aa; Planh; PLANH1; plas; Plasminogen activator inhibitor 1; plasminogen activator inhibitor I; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); putative plasminogen activator inhibitor-1; RATPAI1A; serine (or cysteine) peptidase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; serine (or cysteine) proteinase inhibitor, member 1; serpin E1; serpin family E member 1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; SERPINE1; SERPINE-1

PAI1 Proteins

Protein Information

Synonyms

Custom Antibody Service

We're here to help

Your items have has been added!