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          • Proteins & Peptides ›
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          ARK5 Proteins

          ARK5 Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed?... ARK5 Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... ARK5 Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.... ARK5 Human recombinant proteins are validated for use in the following applications: Kinase Assay. Available Product Grades: RUO. Browse 1 protein. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

          Protein Information

          NUAK1 (ARK5) is a serine/threonine kinase that plays a role in many cellular functions. The overexpression of this kinase has been associated with tumor invasion and metastasis (colorectal neoplasm). Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate in transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR. Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with STK11, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair.

          Synonyms

          AMP-activated protein kinase family member 5; AMPK-related protein kinase 5; ARK5; AU014801; AW494241; B230104P22Rik; Kiaa0537; NUAK family kinase 1; NUAK family SNF1-like kinase 1; NUAK family, SNF1-like kinase, 1; NUAK1; Omphalocele kinase 1; Omphk1; RGD1309956; ZNUAK family, SNF1-like kinase, 1

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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

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          Invitrogen
          Human NUAK1 (ARK5), His Tag Recombinant Protein
          Invitrogen
          Human NUAK1 (ARK5), His Tag Recombinant Protein
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          Cat # PV4127

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