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Invitrogen
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Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-51964. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
TRIM22 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. It localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 50 kDa-stimulated trans-acting factor; E3 ubiquitin-protein ligase TRIM22; RING finger protein 94; RING-type E3 ubiquitin transferase TRIM22; Staf-50; stimulated trans-acting factor (50 kDa); tripartite binding motif 22; tripartite motif protein TRIM22; tripartite motif-containing 22; Tripartite motif-containing protein 22
Gene Aliases: GPSTAF50; RNF94; STAF50; TRIM22
UniProt ID: (Human) Q8IYM9
Entrez Gene ID: (Human) 10346
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