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Invitrogen
Human TEP1 Synthetic Peptide
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Product Details
PEP-0474
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 20 amino acids near the amino terminus of human TP1
PEP-0474 can be used as a blocking peptide with polyclonal antibody PA5-20354.
Target Information
Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p240; p80 telomerase homolog; Telomerase protein 1; Telomerase protein component 1; Telomerase-associated protein 1; TROVE domain family, member 1
Gene Aliases: p240; TEP1; TLP1; TP1; TROVE1; VAULT2
UniProt ID: (Human) Q99973
Entrez Gene ID: (Human) 7011
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