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Invitrogen
Human SLC5A12 (aa 202-236) Control Fragment Recombinant Protein
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Product Details
RP-104133
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
QGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRH
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (80%), Rat (80%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63910. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Sodium-coupled monocarboxylate transporter 2; sodium-iodide related cotransporter; solute carrier family 5 (sodium/glucose cotransporter), member 12; solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12; Solute carrier family 5 member 12
Gene Aliases: SLC5A12; SMCT2
UniProt ID: (Human) Q1EHB4
Entrez Gene ID: (Human) 159963
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