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          • Proteins & Peptides ›
          • CXCL12 gamma Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Human CXCL12 (SDF-1g) Recombinant Protein, PeproTech®

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          Cite Human CXCL12 (SDF-1g) Recombinant Protein, PeproTech®

          Product Details

          300-28G-10UG

          Applications
          Tested Dilution
          Publications

          Functional Assay (Functional)

          Assay-dependent
          -
          Product Specifications

          Species

          Human

          Expression System

          E. coli

          Amino acid sequence

          KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKGR REEKVGKKEK IGKKKRQKKR KAAQKRKN

          Molecular weight

          11.6 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥98% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Determined by its ability to chemoattract human T cells.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          Recombinant Human CXCL12 (SDF-1g) is a 11.6 kDa protein containing 98 amino acid residues.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          The SDF-1 proteins are stromal-derived CXC chemokines that signal primarily through the CXCR4 receptor. SDF-1 proteins exert chemotactic activity over a broad range of immune system cell types and may also be involved in other processes including metastasis of certain cancers, inflammation, and angiogenesis. Additionally, SDF-1 can suppress HIV entry into cells expressing the CXCR4 receptor. Five isomers of SDF-1 have been found with SDF-1alpha being the predominant form, expressing in a wide range of cell types. The SDF-1gamma isoform is distinctive in that it contains a highly basic C-terminal region, which presumably is the reason for its high binding affinity to gylcosaminoglycans (GAG) and heparin sulfate (HS). Consequently, most of SDF-1gamma exists in a cell- and membrane-bound form, which confers greater stability compared to other isoforms via increased resistance to proteolytic degradation. SDF-1gamma binds with reduced affinity to the CXCR4 receptor when compared to the alpha and beta isoforms, but because of its increased stability can, over time, exert equal or greater activity when compared to other SDF-1 isoforms. SDF-1gamma expression has been found primarily in the heart (human and mouse) and in the brain and central nervous system (rat).

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; SDF-1; Stromal cell-derived factor 1; Stromal-Cell Derived Factor-1

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          Gene Aliases: CXCL12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1

          View more View less

          UniProt ID: (Human) P48061

          View more View less

          Entrez Gene ID: (Human) 6387

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          It has to be done as per old AB suggested Products section.
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