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Invitrogen
Human Apoptosis-Enhancing Nuclease (aa 16-92) Control Fragment Recombinant Protein
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Product Details
RP-98170
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (62%), Rat (62%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-111279. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis-enhancing nuclease; interferon stimulated exonuclease gene 20kDa-like 1; Interferon-stimulated 20 kDa exonuclease-like 1
Gene Aliases: AEN; ISG20L1; pp12744; SBBI58
UniProt ID: (Human) Q8WTP8
Entrez Gene ID: (Human) 64782
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