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Invitrogen
Human ATL1 (aa 301-424) Control Fragment Recombinant Protein
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Product Details
RP-88910
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
IPWLLSPESLDIKEINGNKITCRGLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVATAKDTYNKKMEEICGGDKPFLAPNDLQTKHLQLKEESVKLFRGVKKMGGEEFSRRYLQQLESE
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (97%), Rat (97%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55652. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The protein encoded by this gene is a GTPase and a Golgi body transmembrane protein. The encoded protein can form a homotetramer and has been shown to interact with spastin and with mitogen-activated protein kinase kinase kinase kinase 4. This protein may be involved in axonal maintenance as evidenced by the fact that defects in this gene are a cause of spastic paraplegia type 3. Three transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATL-1; ATL1 alpha; ATL1 beta; ATL1 gamma; ATL1-delta; Atlastin-1; BCL-11B; Bcl11B; BCL11B/TRDC fusion; Brain-specific GTP-binding protein; Ctip 2; CTIP-2; CTIP2; GBP-3; GTP-binding protein 3; Guanine nucleotide-binding protein 3; guanylate-binding protein 3; hGBP3; hRit1; hRIT1 alpha; Rit 1; Rit1; Spastic paraplegia 3 protein A; ZNF856B
Gene Aliases: AD-FSP; ATL1; atlastin1; FSP1; GBP3; HSN1D; SPG3; SPG3A
UniProt ID: (Human) Q8WXF7
Entrez Gene ID: (Human) 51062
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