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Invitrogen
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Immunogen sequence: LHSAEQLKAQ AIDFINRCSV LRQLGCKDGK NWNSNQATDI METSGWKSMI QSHPHLVA
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 97%.
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIB homolog 2; Roadkill homolog 2; speckle type POZ protein like; Speckle-type POZ protein-like
Gene Aliases: BTBD33; SPOPL
UniProt ID: (Human) Q6IQ16
Entrez Gene ID: (Human) 339745
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