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Proteintech
SPAG6 Polyclonal Antibody
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Product Details
12462-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SPAG6 Fusion Protein Ag3130 (109-458 aa encoded by BC030585)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AVGKHSPQL AQAIVDCGAL DTLVICLEDF DPGVKEAAAW ALRYIARHNA ELSQAVVDAG AVPLLVLCIQ EPEIALKGIA ASALSDIVKH SPELAQTVVD AGAVAHLAQM ILNPDAKLKH QILSALSQVS KHSVDLAEMV VEAEIFPVVL TCLKDKDEYV KKNASTLIRE IAKHTPELSQ LVVNAGGVAA VIDCIGSCKG NTRLPGIMML GYVAAHSENL AMAVIISKGV PQLSVCLSEE PEDHIKAAAA WALGQIGRHT PEHARAVAVT NTLPVLLSLY MSTESSEDLQ VKSKKAIKNI LQKCTYLPAL EPFLYDAPPN ILKHVVGQFS KVLFPWIFRY TSAEGGQLST T (109-458 aa encoded by BC030585)
Target Information
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: axoneme central apparatus protein; Protein PF16 homolog; Repro-SA-1; Sperm flagellar protein; Sperm-associated antigen 6; testicular tissue protein Li 176
Gene Aliases: CT141; PF16; Repro-SA-1; RGD1310892; SPAG6
UniProt ID: (Human) O75602
Entrez Gene ID: (Human) 9576, (Rat) 360747, (Mouse) 381350
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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