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Invitrogen
RKHD4 Polyclonal Antibody
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Product Details
PA5-20639
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to 14 amino acid synthetic peptide near the carboxy terminus of human RKHD4. The immunogen is located within amino acids 420-470 of RKHD4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11156606
Product Specific Information
Suggested positive controls are mouse thymus or rat thymus tissue lysate.
PA5-20639 can be used with blocking peptide PEP-0759.
Target Information
Rkhd4, also known as MEX3A is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd4, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. While Rkhd2 has been suggested to be associated with susceptibility to essential hypertension type 8, the function of Rkhd4 remains unknown. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mex-3 RNA binding family member A; mex3 homolog A; ring finger and KH domain containing 4; ring finger and KH domain containing protein; RING finger and KH domain-containing protein 4; RNA-binding protein MEX3A
Gene Aliases: 2700083E18Rik; Gm411; MEX-3A; MEX3A; RGD1564904; RKHD4
UniProt ID: (Human) A1L020
Entrez Gene ID: (Human) 92312, (Rat) 310631, (Mouse) 72640
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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