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Proteintech
PSMB10 Monoclonal Antibody (1G8C1)
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Product Details
66403-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1G8C1
Immunogen
PSMB10 Fusion Protein Ag8835 (1-273 aa encoded by BC017198)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLKPALEPR GGFSFENCQR NASLERVLPG LKVPHARKTG TTIAGLVFQD GVILGADTRA TNDSVVADKS CEKIHFIAPK IYCCGAGVAA DAEMTTRMVA SKMELHALST GREPRVATVT RILRQTLFRY QGHVGASLIV GGVDLTGPQL YGVHPHGSYS RLPFTALGSG QDAALAVLED RFQPNMTLEA AQGLLVEAVT AGILGDLGSG GNVDACVITK TGAKLLRTLS SPTEPVKRSG RYHFVPGTTA VLTQTVKPLT LELVEETVQA MEVE (1-273 aa encoded by BC017198)
Target Information
The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatibility complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Low molecular mass protein 10; Macropain subunit MECl-1; MGC1665; Multicatalytic endopeptidase complex subunit MECl-1; OTTHUMP00000174858; proteasome (prosome, macropain) subunit, beta type, 10; proteasome beta 10 subunit; proteasome catalytic subunit 2i; Proteasome MECl 1; Proteasome MECl-1; proteasome subunit beta 7i; Proteasome subunit beta type-10; Proteasome subunit beta-2i; proteasome subunit MECL1; PSMB 10
Gene Aliases: beta2i; LMP10; MECL1; PSMB10
UniProt ID: (Human) P40306, (Rat) Q4KM35
Entrez Gene ID: (Human) 5699, (Pig) 733626, (Rat) 291983
cell morphogenesis
T cell proliferation
proteolysis involved in cellular protein catabolic process
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
humoral immune response
viral process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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