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Abnova
MSLN Polyclonal Antibody, MaxPab™
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Product Details
H00010232-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MSLN (AAH03512.1, 1 a.a. approximately 621 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MALPTARPLL GSCGTPALGS LLFLLFSLGW VQPSRTLAGE TGQAAPLDGV LANPPNISSL SPRQLLGFPC AEVSGLSTER VRELAVALAQ KNVKLSTEQL RCLAHRLSEP PEDLDALPLD LLLFLNPDAF SGPQACTRFF SRITKANVDL LPRGAPERQR LLPAALACWG VRGSLLSEAD VRALGGLACD LPGRFVAESA EVLLPRLVSC PGPLDQDQQE AARAALQGGG PPYGPPSTWS VSTMDALRGL LPVLGQPIIR SIPQGIVAAW RQRSSRDPSW RQPERTILRP RFRREVEKTA CPSGKKAREI DESLIFYKKW ELEACVDAAL LATQMDRVNA IPFTYEQLDV LKHKLDELYP QGYPESVIQH LGYLFLKMSP EDIRKWNVTS LETLKALLEV NKGHEMSPQV ATLIDRFVKG RGQLDKDTLD TLTAFYPGYL CSLSPEELSS VPPSSIWAVR PQDLDTCDPR QLDVLYPKAR LAFQNMNGSE YFVKIQSFLG GAPTEDLKAL SQQNVSMDLA TFMKLRTDAV LPLTVAEVQK LLGPHVEGLK AEERHRPVRD WILRQRQDDL DTLGLGLQGG IPNGYLVLDL SVQEALSGTP CLLGPGPVLT VLALLLASTL A
Target Information
Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. While the biological functions of both Mesothelin and MPF remain speculative, high-levels of expression in cancerous tissues compared to limited distribution in normal tissues strongly suggests their involvement in tumorigenesis. Both have been demonstrated to promote tumor cell proliferation, migration,anchorage-independent growth, and tumor progression; demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAK1; CAK1 antigen; megakaryocyte potentiating factor; Mesothelin; Pre-pro-megakaryocyte-potentiating factor; SMR; soluble MPF mesothelin related protein
Gene Aliases: MPF; MSLN; SMRP
UniProt ID: (Human) Q13421
Entrez Gene ID: (Human) 10232
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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