MUbio

Lactoferrin Monoclonal Antibody (67D9)

View all (86) Lactoferrin antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MUB2002P

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

67D9

Immunogen

Lactoferrin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Monoclonal antibodies 67D2, 67D9 and 67F12 bind to the same or overlapping epitopes on an 80 Kd antigen indiCated as MAM-5. On frozen as well as on formalin-fixed lactating mammary gland sections, a very strong reaction in secretion products is observed. Occasionally, preexisting ducts react in some of the mammary tumors, indiCating an enhanced secretory activity in these parts of the mammary gland.

The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.

Target Information

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CKRX; epididymis luminal protein 110; Growth-inhibiting protein 12; Kaliocin 1; kaliocin-1; Kaliocin1; lactoferricin; Lactoferricin H; Lactoferrin; lactoferroxin; LactoferroxinA; LactoferroxinB; LactoferroxinC; Lactotransferrin; Lfcin H; LfcinH; minisatellite 10r detected by probe MMS10; N lobe; neutrophil lactoferrin; Talalactoferrin

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Gene Aliases: Csp82; GIG12; HEL110; HLF2; LF; LTF; MMS10R; Ms10r

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UniProt ID: (Human) P02788, (Mouse) P08071

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Entrez Gene ID: (Human) 4057, (Mouse) 17002

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Function(s)
DNA binding serine-type endopeptidase activity iron ion binding protein binding heparin binding protein serine/threonine kinase activator activity peptidase activity serine-type peptidase activity hydrolase activity metal ion binding
Process(es)
ossification regulation of cytokine production innate immune response in mucosa immune system process proteolysis transport ion transport antibacterial humoral response antifungal humoral response negative regulation of lipopolysaccharide-mediated signaling pathway regulation of tumor necrosis factor production negative regulation of ATPase activity positive regulation of osteoblast proliferation positive regulation of toll-like receptor 4 signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral process negative regulation of viral genome replication positive regulation of osteoblast differentiation negative regulation of viral process positive regulation of NF-kappaB transcription factor activity iron ion homeostasis bone morphogenesis positive regulation of protein serine/threonine kinase activity negative regulation of single-species biofilm formation in or on host organism positive regulation of chondrocyte proliferation retina homeostasis transcription, DNA-templated humoral immune response iron assimilation by chelation and transport negative regulation of apoptotic process cellular protein metabolic process cell redox homeostasis positive regulation of bone mineralization involved in bone maturation negative regulation of tumor necrosis factor (ligand) superfamily member 11 production negative regulation of osteoclast development
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