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Invitrogen
GITR (TNFRSF18) Monoclonal Antibody (T9P4G4-D7), FITC
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Product Details
MA5-45910
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
T9P4G4-D7
Immunogen
Synthetic peptide from the C-terminal of Human Tumor Necrosis Factor Receptor Superfamily, Member 18
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
A 1:1,000 dilution of MA5-45910 was sufficient for detection of Tumor Necrosis Factor Receptor Superfamily, Member 18 in 15 µg of Mouse Skeletal Muscle by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.|Detects 25 kDa.
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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