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PA1-27982 detects Eotaxin from mouse, human samples.
PA1-27982 has been successfully used in neutralization and control applications. The ND50 is approximately 1-3 ug/ml in the presence of 0.05 ug/ml of human eotaxin, using CCR3 transfected Y3 cells in a chemotaxis assay.
The PA1-27982 immunogen is: Purified E. coli-derived recombinant human eotaxin
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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