Invitrogen

EMR1 Polyclonal Antibody

EMR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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EMR1 Antibody (PA5-21399) in IHC (P)

Immunohistochemical analysis of paraffin-embedded PC13 xenograft, using EMR1 (Product # PA5-21399) antibody at 1:100 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

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Product Details

PA5-21399

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 626 and 886 of EMR1 (Uniprot ID#Q14246)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

AB_11154537

Product Specific Information

Recommended positive controls: Jurkat, Raji, K562, C8D30, NIH-3T3, Raw264.7, C2C12, rat liver.

Predicted reactivity: Mouse (86%), Rat (84%), Dog (84%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

EMR1 has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. EMR1 is the human ortholog of murine F4/80 but unlike F4/80, the expression of EMR1 in humans is restricted to eosinophils and is not expressed on macrophage populations.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Prophylactic treatment with CN-105 improves functional outcomes in a murine model of closed head injury.

Experimental brain research

Van Wyck D,Kolls BJ,Wang H,Cantillana V,Maughan M,Laskowitz DT

PA5-21399 was used in Immunohistochemistry to evaluate whether CN-105, a 5-amino acid apolipoprotein E (ApoE) mimetic peptide previously shown to modify the post-traumatic neuroinflammatory response, would maintain its neuroprotective effects if administered prior to closed-head injury in a clinically relevant murine model.

Thu Sep 01 00:00:00 UTC 2022

Accelerated Generation of Extra-Islet Insulin-Producing Cells in Diabetic Rats, Treated with Sodium Phthalhydrazide.

International journal of molecular sciences

Abidov MT,Sokolova KV,Gette IF,Danilova IG

PA5-21399 was used in Immunohistochemistry (Paraffin), Western Blot to find that APH modulates macrophage production and increases the proliferative activity of pancreatic ß-cells.

Wed Apr 13 00:00:00 UTC 2022

Cardioprotective actions of relaxin.

Molecular and cellular endocrinology

Martin B,Romero G,Salama G

PA5-21399 was used in Immunocytochemistry-immunoflourescence to investigate the mechanisms underlying the hormone relaxin''s role in pregnancy.

Wed May 01 00:00:00 UTC 2019

Relaxin reverses inflammatory and immune signals in aged hearts.

PloS one

Martin B,Gabris-Weber BA,Reddy R,Romero G,Chattopadhyay A,Salama G

PA5-21399 was used in Immunohistochemistry-immunofluorescence to support the hypothesis that relaxin alters gene transcription and suppresses inflammatory pathways and genes associated with HF and aging.

Wed Feb 21 00:00:00 UTC 2018

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