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Invitrogen
CDKL5 Recombinant Rabbit Monoclonal Antibody (1H57L44)
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FIGURE: 1 / 5
CDKL5 Antibody (703756) in ICC/IF
For immunofluorescence analysis, SH-SY5Y cells were fixed and permeabilized for detection of endogenous CDKL5 using Anti-CDKL5 Recombinant Rabbit Monoclonal Antibody (Product # 703756, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CDKL5 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Pro... View More
Product Details
703756
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
1H57L44
Immunogen
Protein corresponding to human CDKL5 [aa636-aa774]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2866472
Product Specific Information
This antibody is predicted to react with Bovine.
Target Information
CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin dependent kinase 5 transcript; Cyclin-dependent kinase-like 5; RP1-245G19.3; serine/threonine kinase 9; Serine/threonine-protein kinase 9
Gene Aliases: BC038161; CDKL5; CFAP247; EIEE2; ISSX; STK9
UniProt ID: (Human) O76039, (Mouse) Q3UTQ8
Entrez Gene ID: (Human) 6792, (Mouse) 382253, (Rat) 100362725
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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